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Metabolic reprogramming is now recognised as a critical aberration facilitating the growth and proliferation of many cancers. There is a compelling body of evidence showing that signaling pathways that drive oncogenesis, also trigger major alterations in nutrient uptake and metabolism, while mutations in a number of metabolic enzymes are known to cause certain types of cancer. In addition to changes in metabolism at the level of the tumour, there are also strong links between metabolic diseases, such as obesity and diabetes, and cancer prevalence, severity and disease progression. This extensive interplay between oncogenic signaling and intermediary metabolism has raised the possibility that targeting metabolic pathways may be a viable therapeutic approach for preventing and treating cancer.

Thus the goal of this meeting is to engage a diverse group of scientists with expertise in nutrient metabolism, cancer biology, signal transduction and network modeling to explore and discuss the latest developments in metabolic regulation in cancer. This meeting was held for the first time in 2015 at the Garvan Institute and was a great success.

The confirmed plenary speaker is Professor Ralph Deberardinis from UT Southwestern Medical Centre. Ralph’s research focus is to integrate cellular signal transduction and metabolism during both normal cell proliferation and tumorigenesis. He is also an attending physician in the Division of Pediatric Genetics and Metabolism at Children’s Medical Center, where he is involved in the diagnosis and care of children with inborn errors of metabolism. He is an outstanding attraction to the meeting.

We also have a distinguished list of plenary speakers spanning the areas of Immuno-metabolism and Cancer, Metabolic Disease, Lifestyle Interventions & Cancer, Novel Metabolic Pathways in Cancer and Cancer Metabolism and Therapeutics.

As was the philosophy of the first meeting, we welcome scientists at all levels and particularly encourage students and postdocs to present their work. There will be a number of selected oral presentations and poster presentations that will be held over both evenings of the meeting.

We look forward to seeing you at the meeting!

Matthew Watt
(Monash University)
Renea Taylor
(Monash University)
Lorey Smith
(Peter MacCallum Cancer Centre)
Tony Tiganis
(Monash University)

 

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